Study the Effect of the Environmental Pollutants Emitted from the Generators on the Receptors Tyrosine Kinase Using Bioinformatics Tools

Author:   Manar Dawood Salman ,Maitham Abdullah Sultan , Hasan Kadim Nimr and Baidaa Hamad Obaid

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Abstract

Receptor Tyrosine Kinases (RTKs) play very important role in many biological functions, All of them are activated by ligands bind to extracellular regions of RTKs. Deregulation of RTKs signaling causing mutations these mutations can change the structure and function leads to many human diseases, especially cancer therefor study in this research the affinity of binding between pollutants that emitted from electrical generators as a ligands and tyrosine kinase receptors as target protein receptor structure complexes using Insilico consisting of PYRX virtual screening tool increases docking accuracy with vina and Auto Dock scoring. Using the discovery studio visualizer and PYRX virtual screening tool, a collection of exemplary compounds were molecularly docked into the target receptor of protein active site inside (A) chain. Results of this study showed that pollutants (Benzopyrene, Hydroxypyrene, Naphthalene, CO2, Benzene)   have a significant effect on the proteins which were (-8.8, -8.3, -6.5, -5.8, - 4.5) respectively. RTKs considered the main carrier of signals regulates cellular differentiation, proliferation and transmits extracellular signals into the cell, from this results concluded the continuous exposure to these pollutants leads to many diseases and mutations and this leads to cancer.

Keywords: In silico, RTKs, Generators, Pubchem, PYRX.